STIR. SIP. INVIGORATE.

Allysian's team of experts has come together to create the world's most powerfully enhanced coffee.

Certified fair trade and organic, Allysian Rise releases the robust flavours of 100% Arabica coffee crystals, enhanced with clinically supported natural extracts such as Neurofactor™.

Allysian Rise is composed of a synergistic blend of active ingredients in the perfect proportions and optimal potencies to stimulate the production of neuroprotective factors, including BDNF (Brain Derived Neurotrophic Factor), that are vital to learning, memory, and overall brain health.

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+ INGREDIENTS

Organic Colombian Arabica Coffee

Our team of experts sampled coffees from all around the world and came to a unanimous decision on 100% Arabica beans. The combination of perfect growing conditions, ultra high-quality beans, and highly dedicated and skilled coffee growers, means a premium coffee with a deliciously robust flavour profile.

  • Certified Fair Trade
  • Certified Organic
  • Certified Kosher

Coffee Fruit Concentrate

Standardized to 40% coffee fruit polyphenols

Patented by the undisputed world leaders in the research of coffee fruit. Selectively hand-picked at their nutritional peak, providing a unique and superior profile of polyphenols to support cognitive health.

How It Works

  • Contains a superior profile of polyphenols, linked to a wide array of health benefits
  • Stimulates production of brain-derived neurotrophic factor (BDNF)

BDNF is a protein inside nerve cells, helping to nurture, protect, and propel the growth and function of neurons that play a key role in the central and peripheral nervous system.

  • Vital to brain and nerve health
  • Highly active in areas of the brain involved in learning, memory, and higher thinking
  • Naturally decreases with age
  • Low levels linked to impaired learning, anxiety, and depression

References

NeuroFactor™ significantly increases BDNF levels

Neurofactor™ References

NeuroFactor™ products are protected by US and foreign patents and pending applications. NeuroFactor™ is a trademark of VDF FutureCeuticals, Inc. used under license.

  1. Acheson, A., Conover, J.C., Fandl, J.P., DeChiara, T.M., Russell, M., Thadani, A., et al. (1995). A BDNF autocrine loop in adult sensory neurons prevents cell death. Nature, 374(6521), 450-453.
  2. Bekinschtein, P., Cammarota, M., Katche, C., Slipczuk, L., Rossato, J.I., Goldin, A., et al. (2008). BDNF is essential to promote persistence of long-term memory storage. Proceedings of the National Academy of Sciences of the United States of America, 105(7), 2711-2716.
  3. Binder, D.K., & Scharfman, H.E. (2004). Brain-derived neurotrophic factor. Growth Factors, 22(3), 123-131.
  4. Dinoff, A., Herrmann, N., Swardfager, W., & Lanctot, K.L. (2017). The effect of acute exercise on blood concentrations of brain-derived neurotrophic factor (BDNF) in healthy adults: a meta-analysis. Eur J Neurosci. doi:10.1111/ejn.13603.
  5. Makhathini, K.B., Abboussi, O., Stein, D., Mabandla, M.V., & Daniels, W.M.U. (2017). Repetitive stress leads to impaired cognitive function that is associated with DNA hypomethylation, reduced BDNF, and a dysregulated HPA axis. Int J Dev Neurosci. doi:10.1016/j.ijdevneu.2017.04.004.
  6. Pencea, V., Bingaman, K.D., Wiegand, S.J., & Luskin, M.B. (2001). Infusion of brain-derived neurotrophic factor into the lateral ventricle of the adult rat leads to new neurons in the parenchyma of the striatum, septum, thalamus, and hypothalamus. The Journal of Neuroscience, 21(17), 6706-6717.
  7. Reyes-Izquierdo, T., Argumedo, R., Shu, C., Nemzer, B., & Pietrzkowski, Z. (2013). Stimulatory effect of whole coffee fruit concentrate powder on plasma levels of total and exosomal brain-derived neurotrophic factor in healthy subjects: an acute within-subject clinical study. Food and Nutrition Sciences, 4, 984-990.
  8. Reyes-Izquierdo, T., Nemzer, B., Shu, C., Huynh, L., Argumedo, R., Keller, R., & Pietrzkowski, Z. (2013). Modulatory effect of coffee fruit extract on plasma levels of brain-derived neurotrophic factor in healthy subjects. British Journal of Nutrition, 110(3), 420-425.
  9. Sleiman, S.F., Henry, J., Al-Haddad, R., El Hayek, L., Haidar, E.A., Stringer, T., et al. (2016). Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body B-hydroxybutyrate. Elife. doi:10.7554/eLife.15092.
  10. Yamada, K., & Nabeshima, T. (2003). Brain-derived neurotrophic factor/TrkB signaling in memory processes. Journal of Pharmacological Sciences, 91(4), 267-270. 11. Zigova, T., Pencea, V., Wiegand, S.J., & Luskin, M.B. (1998). Intraventricular administration of BDNF increases the number of newly generated neurons in the adult olfactory bulb. Molecular and Cellular Neurosciences, 11(4), 234-245.

Organic Lion's Mane

Enjoyed as a food in Japan and China and used for centuries in traditional Chinese medicine, Lion's Mane has been shown to be effective in improving cognitive function and supporting nerve health.

How It Works

  • Contains compounds that promote the synthesis of Nerve Growth Factor, which is involved in the regulation, growth, and survival of neurons in the central nervous system
  • Enhances myelination of neurons for faster communication between nerves*

In a 2009 study, older adults with mild cognitive impairment who took Lion's Mane for 16 weeks had significant improvements in cognitive function tests when compared to placebo.

References

LIONS MANE REFERENCES

  1. Allen, S.J., & Dawbarn, D. (2006). Clinical relevance of the neurotrophins and their receptors. Clinical Science, 110(2), 175-191.
  2. Althaus, H.H. (2004). Remyelination in multiple sclerosis: a new role for neurotrophins? Progress In Brain Research, 146, 415-432.
  3. Chaldakov, G.N., Tonchev, A.B., & Aloe, L. (2009). NFG and BDNF: from nerves to adipose tissue, from neurokines to metabokines. Rivista Di Psichiatria, 44(2), 79-87.
  4. Lai, P.L., Naidu, M., Sabaratnam, V., Wong, K.H., David, R.P., Kuppusamy, U.R., Abdullah, N., & Malek, S.N. (2013). Neurotrophic properties of the Lion’s mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia. Int J Med Mushrooms, 15(6), 539- 554.
  5. Mori, K., Inatomi, S., Ouchi, K., Azumi, Y., & Tuchida, T. (2009). Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial.
  6. Mori, K., Obara, Y., Moriya, T., Inatomi, S., & Nakahata, N. (2011). Effects of Hericium erinaceus on amyloid B(25-35) peptide-induced learning and memory deficits in mice. Biomed Res, 32(1), 67-72.
  7. Nagano, M., Shimizu, K., Kondo, R., Hayashi, C., Sato, D., Kitagawa, K., & Ohnuki, K. (2010). Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake. Biomed Res, 31(4), 231-237.
  8. Tuszynski, M.H., & Blesch, A. (2004). Nerve growth factor: from animal models of cholinergic neuronal degeneration to gene therapy in Alzheimer's disease. Progress In Brain Research, 146, 441-449.
  9. Tuszynski, M.H., Yang, J.H., Barba, D., U, H.S., Bakay, R.A., Pay, M.M., et al. (2015). Nerve growth factor gene therapy: activation of neuronal responses in Alzheimer disease. JAMA Neurology, 72, 1139-1147.
  10. Villoslada, P., & Genain, C.P. (2004). Role of nerve growth factor and other trophic factors in brain inflammation. Progress In Brain Research, 146, 403-414.
  11. Wong, K.H., Naidu, M., David, R.P., Bakar, R., & Sabaratnam, V. (2012). Neuroregenerative potential of lion’s mane mushroom, Hericium erinaceus (Bull.:Fr.) Pers. (higher Basidiomycetes), in the treatment of peripheral nerve injury. Int J Med Mushrooms, 14(5), 427- 446

L-Theanine

An amino acid naturally occurring in tea leaves, known to significantly promote relaxation and focus, improve sleep and mood, and reduce stress and anxiety. L-theanine works synergistically with caffeine, enhancing the positive effects while reducing tiredness, headaches, and jitteriness.

How It Works

  • Promotes alpha wave production in the brain (this wave frequency helps us calm down and feel relaxed)
  • Increases levels of glutathione, a potent antioxidant
  • Increases levels of GABA, a neurotransmitter that is found naturally in the brain and has a calming effect on healthy individuals
  • Low levels of GABA have been found in those with certain types of anxiety disorders

In a 2012 study of healthy adults, those who took a single administration of L-theanine experienced reduced tension and anxiety scores, compared to placebo.

References

L-THEANINE REFERENCES

  1. Einother, S.J., Martens, V.E., Rycroft, J.A., & De Bruin, E.A. (2010). L-theanine and caffeine improve task switching but not intersensory attention or subjective alertness. Appetite, 54(2), 406-409.
  2. Foxe, J.J., Morie, K.P., Laud, P.J., Rowson, M.J., de Bruin, E.A., & Kelly, S.P. (2012). Assessing the effects of caffeine and theanine on the maintenance of vigilance during a sustained attention task. Neuropharmacology, 62(7), 2320-2327.
  3. Giesbrecht, T., Rycroft, J.A., Rowson, M.J., & De Bruin, E.A. (2010). The combination of L- theanine and caffeine improves cognitive performance and increases subjective alertness. Nutr Neurosci, 13(6), 283-290.
  4. Haskell, C.F., Kennedy, D.O., Milne, A.L., Wesnes, K.A., & Scholey, A.B. (2008). The effects of L- theanine, caffeine and their combination on cognition and mood. Biological Psychology, 77(2), 113-122.
  5. Higashiyama, A., Htay, H.H., Ozeki, M., Juneja, L.R., & Kapoor, M.P. (2011). Effects of L- theanine on attention and reaction time response. Journal of Functional Foods, 3(3), 171-178.
  6. Kahathuduwa, C.N., Dassanayake, T.L., Amarakoon, A.M., & Weerasinghe, V.S. (2016). Acute effects of theanine, caffeine and theanine-caffeine combination on attention. Nutr Neurosci. doi: 10.1080/1028415X.2016.1144845.
  7. Owen, G.N., Parnell, H., De Bruin, E.A., & Rycroft, J.A. (2008). The combined effects of L- theanine and caffeine on cognitive performance and mood. Nutr Neurosci, 11(4), 193-198.
  8. Rogers, P.J., Smith, J.E., Heatherley, S.V., & Pleydell-Pearce, C.W. (2008). Time for tea: mood, blood pressure and cognitive performance effects of caffeine and theanine administered alone and together. Psychopharmacology (Berl), 195(4), 569-577.
  9. Timmcke, J.Q., Juneja, L.R., & Kapoor, M.P. (2008). Efficacy and short-term safety of L- theanine in randomized, double-blind, parallel-group study. The FASEB Journal, 22(2).
  10. Yoto, A., Motoki, M., Murao, S., & Yokogoshi, H. (2012). Effects of L-theanine or caffeine intake on changes in blood pressure under physical and psychological stresses. J Physiol Anthropol, 31(1), 28-36.

Supplement Facts

Serving Size 1 sachet (2.8 g)

  Amount Per Serving % Daily Value*
Calories 10
Fat 0 g
Saturated 0 g
+Trans Fat 0 g 0
Carbohydrate 2 g
Fibre 0 g
Sugar 0 g 0%
Protein 1 g
Cholesterol 0 g
Sodium 1 mg 0%
Potassium 105 mg 3%
Calcium 6 mg 1%
Iron 0 mg 0%

*5% or less is a little. 15% or more is a lot

Dissolve 1 sachet into a 240 mL (8 fl oz.) cup with hot water. Stir and enjoy.

Prepare with hot water:

  • Rich - 180 mL (6 fl oz.)
  • Medium - 240 mL (8 fl oz.)
  • Light - 300 mL (10 fl oz.)

For frequently asked questions or articles visit our Help Centre.

Made In Canada Ethically Sourced No Artificial Preservatives No Artificial Additives No Artificial Colours No Artificial Sweeteners Plant Based

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DELIVERY

Orders received before 1pm Pacific time are shipped the same business days while those received after are shipped the following business day. Delivery times are between 2 to 5 business days depending on your location. Orders received on weekends and holidays are shipped the next business day during regular hours. Orders will have a separate tracking email sent to you once the order is shipped, please be sure to enter an email address where you can receive your tracking information.

RETAIL CUSTOMER RETURN & EXCHANGE POLICY

We guarantee satisfaction for all of our products and customer satisfaction is our top priority. If you are not 100% satisfied with your purchase from Allysian Sciences Inc. you can return your unopened item(s) in their original packaging for a full refund or exchange within 365 days of purchase. Returns must be unopened, in the state you received them, and in the original packaging.

OPENED ITEMS: Allysian Sciences offers a 30 (thirty) day 100% (one hundred percent) unconditional money back guarantee on opened products. Allysian Sciences Inc. will refund, or exchange, opened and/or partially used products if returned within 30 days of the purchase date.

RETURN MERCHANDISE AUTHORIZATION NUMBER: Before returning any item you must obtain an RMA number to be placed on the return package. Please contact us at support@allysian.com or call us @ 604-369-0024 and we will supply you, within one business day, with an RMA number and our return address. Returns without an RMA number or to the incorrect address will not be accepted. If you purchased an Allysian Sciences Inc. product directly from an Independent Affiliate or Distributor (it was not shipped from an Allysian Sciences Inc. location) and are not satisfied, you MUST return the product to your place of purchase.

SHIPPING FEES: The original shipping fees, if any, are non-refundable, and the cost of shipping for the return of your shipment, if any, is at your expense. However, the cost of shipping any exchange items back to you will be covered by Allysian Sciences Inc. Please ship returns only with a trackable shipping method and note the tracking number of your return.